NAR Molecular Biology Database Collection entry number 1010

http://sisyphus.mrc-cpe.cam.ac.uk

Andreeva A.¹, Prlic A.², Hubbard T.J.P.² and Murzin A.G.¹

¹MRC Centre for Protein Engineering, MRC Centre, Hills Rd., Cambridge, CB2 2QH, UK
²Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK

Contact sisyphus@mrc-lmb.cam.ac.uk

The SISYPHUS database contains manually curated multiple structural alignments constructed for a set of proteins with known three-dimensional structures that have revealed non-trivial structural relationships and whose structural similarity is ambiguous when using standard methods for structure comparison. The multiple alignments in the database comprise common structural motifs, structural domains or oligomeric biological units. Thus they capture a variety of protein structural relationships many of which are biologically relevant. The multiple alignments are grouped into different alignment categories and connected by complex non-hierarchical inter-relationships described by DAGs. The SISYPHUS alignments are displayed with SPICE, a browser that provides an integrated view of protein sequences, structures and their annotations.

This work was supported by the MRC strategic grant G0100305.

Go to the abstract in the NAR 2007 Database Issue.

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