NAR Molecular Biology Database Collection entry number 1022

http://bioinformatics.lcd-ustc.org/microkit/

Xue Y.¹, Zhou F.², Fu C.¹, Jin C.¹, Pei S.¹, Xu Y.², and Yao X.^1,3

¹Laboratory of Cellular Dynamics, Hefei National Laboratory for Physical Sciences, University of Science and Technology of China, Hefei, China 230027
²Computational Systems Biology Laboratory, Department of Biochemical and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA
³Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA

Contact yaoxb@ustc.edu.cn or xyn@bmb.uga.edu

Based on the rationale of "seeing is believing", we have collected proteins known to be localized in midbody, centrosome, and/or kinetochore from the literature into this database, MiCroKit. All collected proteins have supportive evidences for subcellular localizations under fluorescent microscope unambiguously. The current version MiCroKit 2.0 provides detailed information for 1,120 such proteins from seven model organisms, including budding & fission yeast, nematode, fruit fly, frog/Xenopus, mouse and human. MiCroKit is accessible from http://bioinformatics.lcd-ustc.org/microkit/ or http://csbl.bmb.uga.edu/~ffzhou/microkit/.

The work is supported, in part, by Chinese Natural Science Foundation (39925018, 30270654 and 30270293), Chinese Academy of Science (KSCX2-2-01), Chinese 973 project (2002CB713700), Chinese Minister of Education (20020358051), American Cancer Society (RPG-99-173-01) and National Institutes of Health (DK56292; CA92080). X. Yao is a Georgia Cancer Coalition Eminent Scholar. F. Zhou and Y. Xu’s work is supported, in part, by the Georgia Cancer Coalition under a “Distinguished Scholar” grant, and National Science Foundation (NSF/DBI-0354771, NSF/ITR-IIS-0407204).

1. Xue Y, Zhou F, Fu C, Jin C, Pei S, Xu Y, Yao X. MiCroKit: An Integrated Database of Midbody, Centrosome and Kinetochore. Submitted.

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