NAR Molecular Biology Database Collection entry number 13

http://www.cbil.upenn.edu/EPConDB

Mazzarelli, J., Brestelli, J., Gorski, R., Liu, J., Manduchi, E., Pinney, D., Schug, J., White, P., Kaestner, K., Stoeckert, C.

Department of Genetics, School of Medicine, and Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104

Contact mazz@pcbi.upenn.edu

EPConDB is a public web site that supports research in diabetes, pancreatic development and beta cell function by providing information about genes expressed in cells of the pancreas. EPConDB displays expression profiles for individual genes and information about transcripts, promoter elements and transcription factor binding sites. Gene expression results are obtained from studies examining tissue expression, pancreatic development and growth, differentiation of insulin-producing cells, islet or beta-cell injury, and genetic models of impaired beta cell function. The expression datasets are derived using different microarray platforms, including the BCBC PancChips and Affymetrix gene expression arrays. Other datasets include semi-quantitative RT-PCR and MPSS expression studies. For selected microarray studies, lists of differentially expressed genes, derived from PaGE analysis, are displayed on the site. EPConDB provides database queries and tools to examine the relationship between a gene, its transcriptional regulation, protein function and expression in pancreatic tissues.

Stringent binding site predictions for transcription factors, relevant to pancreatic and islet gene expression, are included in a transcription factor target gene query. The target genes can then be combined with their expression results from pancreatic studies.

EPConDB is supported by NIDDK grant UO1 56947.

1. Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert CJ Jr, Gradwohl G, Clifton SW, Brown JR, Inoue H, Cras-Meneur C, Permutt MA. Transcriptional Program of the Endocrine Pancreas in Mice and Humans. Diabetes 2003 Jul;52(7):1604-1610.

Go to the abstract in the NAR 2007 Database Issue.

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