NAR Molecular Biology Database Collection entry number 326

http://genecards.weizmann.ac.il/geneannot/

Chalifa-Caspi, V., Shmueli, O., Shmoish, M., Shklar, M.,Rosen, N., Benjamin-Rodrig, H., Yanai, I., Ophir, R., Iny Stein, T., Kats, P., Almashanu, L., Safran, M., Lancet, D.

Departments of Molecular Genetics and Biological Services (Bioinformatics Unit), The Weizmann Institute of Science, 76100, Rehovot, Israel

Contact marilyn.safran@weizmann.ac.il

The GeneAnnot system revises and improves annotation of Affymetrix probe sets. The many-to-many relationship between probe-sets and genes is elucidated by GeneAnnot's direct sequence comparison of probes to Genbank, RefSeq and Ensembl mRNA sequences. Whenever possible, probe sets are related to GeneCards genes (http://bioinfo.weizmann.ac.il/cards), with sensitivity and specificity scores assigned to each probe-set to gene match. The sensitivity score measures how many probes in a probe-set connect to a particular gene;
specificity measures how many other genes match a probe-set, and with how many probes.

If no match to GeneCards is found, probe sets are annotated by their relation to GenBank mRNA sequences and UniGene (http://www.ncbi.nlm.nih.gov/UniGene) clusters.

GeneAnnot results are integrated with the GeneCards (http://bioinfo.weizmann.ac.il/cards), GeneLoc (http://genecards.weizmann.ac.il/geneloc/) and GeneNote (http://genecards.weizmann.ac.il/genenote/) databases. For the list of GeneAnnot/GeneCards publications, see http://bioinfo.weizmann.ac.il/genecards/publications.html.

Go to the abstract in the NAR 2003 Database Issue.

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