NAR Molecular Biology Database Collection entry number 417

http://genome.mc.pref.osaka.jp/BGED/

Kato K., Matoba R., Saito S., Matsubara K.

Taisho Laboratory of Functional Genomics, Nara Institute of Science and Technology, Core Reserach for Evolutional Science and Technology, Japan Science and Technology Corporation, 8916-5, Takayama, Nara, 630-0101, JAPAN

Contact kkato@bs.aist-nara.ac.jp

This database contains gene expression data for various physiological and pathological processes in the mouse brain. The data have been obtained by adaptor-tagged competitive PCR (ATAC-PCR), an advanced version of quantitative PCR. Assayed genes were selected from our mouse brain EST collection deposited in BED (Brain EST Database, http://love2.aist-nara.ac.jp/BED ). The current BGED contains data for 3656 genes. Gene expression data can be retrieved either by ID numbers or by keywords representing functional annotations. The ID numbers include GenBank, RefSeq, SwissProt, Gene Ontology, and BED (our own ID). The keyword search is based either on definition in GenBank, SwissProt and RefSeq, functional annotation of SwissProt database, or Gene Ontology terms. Gene expression data are displayed as mosaic plots. A search function based on the similarity of gene expression is available. Currently, BGED includes data for postnatal development of cerebellar cortex and dentate gyrus of hippocumpus, aging, ischemia and effects of antipsychotic agents.

This work was partly supported by a Grant-in-Aid for Scientific Research on Priority Areas "Genome Science" from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

1. Kato, K. (1997) Adaptor-tagged competitive PCR: a novel method for measuring relative gene expression. Nucleic Acids Res. 25, 4694-4696. http://www.pubmedcentral.gov/articlerender.fcgi?artid=147082 [PMC]
2. Matoba, R., Kato, K., Kurooka, C., Maruyama, C., Sakakibara, Y. and Matsubara, K. (2000) Correlation between gene functions and developmental expression patterns in the mouse cerebellum. Eur. J. Neurosci. 12,1357-1371. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10762364&dopt=Abstract [PubMed]
3. Matoba, R., Saito, S., Ueno, N., Maruyama, C., Matsubara, K. and Kato, K. (2000) Gene expression profiling of mouse postnatal cerebellar development.Physiological Genomics 4,155-164. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11120876&dopt=Abstract [PubMed]
4. Saito, S., Matoba, R., Ueno, N., Matsubara, K. and Kato, K. (2002) Comparison of gene expression profiling during postnatal development of mouse dentate gyrus and cerebellum. Physiological Genomics 8, 131-137. PubMed: 11875191

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