NAR Molecular Biology Database Collection entry number 62

http://www.ebi.ac.uk/RHdb

EMBL Outstation - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

Contact rhdb@ebi.ac.uk

Radiation hybrid maps are chromosome maps that are calculated from RH score vectors. An RH score vector is the pattern of assay results of a particular STS (marker) on a particular panel. The vector consists of 1''s (did amplify) and 0''s (did not amplify). Simplistically speaking, the more similar two score vectors are, the closer the markers are on the chromosome. RH maps are an indispensable alternative to genetic maps as they can include non-polymorphic markers and are also powerful enough to order unresolved genetic clusters of polymorphic STSs. International collaborative projects are producing numbers of these hybrids for the human genome, the mouse genome, the rat genome and others. This in turn allows the generation of a very precise STS map that is indispensable in the study of multifactorial diseases. RHdb is collecting all the raw data (the scores and their associated information) from RH experiment and makes them publicly available on the WWW, FTP server and CORBA servers.

Go to the abstract in the NAR 2001 Database Issue.

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