NAR Molecular Biology Database Collection entry number 797

http://argonaute.uni-hd.de

Shahi P.^1,2,3, Loukianiouk S.¹, Bohne-Lang A.¹, Kenzelmann M.², Küffer S.², Maertens S.², Eils R.³, Gröne H.J.², Gretz N.² and Brors B.³

¹Medical Research Center, University Hospital Mannheim, D-68167 Mannheim, Germany
²Department of Cellular and Molecular Pathology, German Cancer Research Center, D-69120 Heidelberg, Germany
³Department of Theoretical Bioinformatics, German Cancer Research Center, D-69120 Heidelberg, Germany

Contact b.brors@dkfz.de

Argonaute (http://www.ma.uni-heidelberg.de/apps/zmf/argonaute/interface) is a database that provides comprehensive information on mammalian microRNAs (miRNA), their origin and regulated target genes, which are collected from both literature and other databases. Argonaute hosts information on origin of a miRNA, i.e. in which host gene it is encoded, the tissue specificity of its expression and its known or proposed function, its potential target genes including GeneOntology annotation, as well as miRNA families based on their co-expression and proteins known to be involved in miRNA processing. Additionally, target genes are linked to an information retrieval system that provides comprehensive information from sequence databases and a simultaneous search of MEDLINE with all synonyms of a given gene (http://www.ma.uni-heidelberg.de/inst/zmf/affymetrix/evaluation/annotation/ver2/). The web interface allows the user to get information for a single or for multiple miRNAs, either selected or uploaded through a text file. Argonaute currently has information on 839 miRNAs from human, mouse and rat.

Funding was provided by the Deutsche Forschungsgemeinschaft through Graduiertenkolleg 886 and by the German Federal Ministry of Research and Education through grant 01GR0450.

Go to the abstract in the NAR 2006 Database Issue.

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